Suicide Slum made its' first appearance in Star Spangled Comics # 7 (April 1942). At that point it was a neighborhood in New York City, but later, on Earth-One it was revealed to be a neighborhood in Metropolis.
In the Post-Infinite Crisis reality, Suicide Slum is revealed to be on the South side of town. The Super Friends universe seems to be closer to the Pre-Crisis Earth-One continuity, which shows that not to be the case. Suicide Slum is more centralized, west of Downtown Metropolis but still on the central island of New Troy, which is in the center of town.