The Powerpuff Girls was a team of superheroes made up of three grade-school aged girls. They were based in the city of Townsville but they had been present at the Hall of Doom to save Aquaman and Wonder Woman from being murdered by the Legion of Doom. The girls were big fans of the Super Friends, which they considered "Old school."
- The Powerpuff Girls were created by Craig McCracken and Lauren Faust for the Hanna-Barbera animated series of the same name. They were later brought to DC Comics.
- The Powerpuff Girls made their first comic book appearance in Powerpuff Girls# 1 (May 2000).